Mirapex (pramipexole)

Mirapex (pramipexole) is an oral medication used for the treatment of moderate to severe primary restless legs syndrome (RLS). Restless legs syndrome is a medical condition that is described as an urge to move the legs. This desire to move is often coupled with unpleasant sensations occurring in the legs that are relieved by movement.

Why Prescribed

Mirapex is prescribed to treat moderate to severe primary restless legs syndrome, and can also be used in the treatment of Parkinson’s disease. Mirapex, a member of the class of drugs called "dopamine agonists," works by imitating the actions of dopamine in the brain, which also helps to control the tremors in smooth muscle that is associated with Parkinson's disease.

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FDA Approved Uses

Mirapex was approved by the FDA in 1997 for the treatment of RLS.

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Side Effects

The most common side effects associated with Mirapex are headache, nausea, dizziness, drowsiness, trouble sleeping, constipation, unusual weakness, stomach upset and pain, headache and dry mouth.  Mirapex can also cause excessive daytime sleepiness.

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Warnings and Alerts

A Mayo Clinic study released in July of 2005 suggested a possible link between Mirapex and compulsive gambling disorder. This study built upon past studies that found a connection between dopamine agonist drugs and a general rise in compulsive disorders.  Mirapex may also cause you to fall asleep without any warning, even while doing normal daily activities such as driving, and some patients have reported having hallucinations while on the drug.

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Drug Contraindications

Mirapex is contraindicated in patients who have any problems with low blood pressure, dizziness, or becoming light-headed, female patients who are pregnant, breastfeeding, or are planning to become pregnant, patients who drink alcohol or smoke cigarettes, and/or patients who suffer from a sleeping disorder or kidney disease.

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FAQ's

What is restless legs syndrome?

Restless legs syndrome (RLS) is a sensorimotor disorder characterized by abnormal or unpleasant sensations occurring in the legs. These unpleasant sensations can lead to an overwhelming urge to move the legs. Restless legs syndrome gets worse during periods of inactivity or when relaxing, especially during the evening. Restless legs syndrome is sometimes mistaken as a sleep disorder when in fact it is a movement disorder that can affect sleep.

What is the difference between primary and secondary restless legs syndrome?

The cause of primary restless legs syndrome is unknown. Research has shown that half of the time primary restless legs syndrome can be traced to a family history. Secondary restless legs syndrome only occurs as a result of an underlying medical condition such as iron deficiency, end-stage renal disease, pregnancy, diabetes, or Parkinson’s disease. Mirapex is not indicated for the treatment of secondary RLS.

What are the symptoms of RLS?

While RLS symptoms can vary from person to person, they are generally described as burning, creeping, crawling, aching, tingling, or tugging sensations in the legs. These sensations often occur in the lower legs, deep inside the leg. These sensations can also occur in the feet, thighs, trunk, and arms.

Can taking Mirapex contribute to OCD, or Obsessive Compulsive Disorder?

Patients and caregivers should be informed that impulse control disorders/compulsive behaviors may occur while taking Mirapex.

Can I bring a defective drug lawsuit if I have suffered injuries from using Mirapex?

If you or a loved one has developed compulsive urges after taking Mirapex, you may be able to file a claim against the manufacturer and collect financial damages. A defective drug attorney who specializes in pharmaceutical litigation can help determine if you have a valid claim.

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